“Matrixome” Contributes to the Realization of Regenerative Medicine
World’s First Successful iPSC Corneal Transplant at Osaka University
Matrixome’s iMatrix-511MG* contributes to “transplant of corneal epithelial cell sheet prepared from iPS cells to a patient”
Osaka University has announced “the the first case of the world’s first transplant of a corneal epithelial cell sheet prepared from iPS cells”. (link to announcement)
September 2, 2019
A Japanese woman in her forties has become the first person in the world to have her cornea repaired using reprogrammed stem cells.
iMatrix-511 is used as a scaffold protein to coat the culture substrate when maintaining and expanding iPS cells. However, there are other cells that use iMatrix-511 as a scaffold in addition to iPS cells with corneal epithelial being such an example.
The corneal epithelial cell sheet used for this specific transplantation used Matrixome’s technology, specifically iMatrix-511MG which is approved by the Japanese government for use in clinical research and applications.
* iMatrix-511MG: A high-purity purified product of laminin-511E8 fragment, clinical grade product that meets the criteria of biological materials.
Related Reference Papers for iMatrix-511
Co-ordinated ocular development from human iPS cells and recovery of corneal function
Ryuhei Hayashi et al. Nature. 2016 Mar 17; 531(7594):376-80.
Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages
Shun Shibata et al. Cell Rep. 2018 Nov 6; 25(6):1668-1679.e5.
Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells.
Ryuhei Hayashi et al. Nat Protoc. 2017 Apr; 12(4):683-696.
Cell-Type-Specific Adhesiveness and Proliferation Propensity on Laminin Isoforms Enable Purification of iPSC-Derived Corneal Epithelium.
Shibata, Shun, et al. Stem Cell Reports. 2020 Apr 14; 14(4):663-676.